Understanding TreatmentOptions in
Cutaneous Lymphoma
Cutaneous B-Cell Lymphomas
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SECTION3:
CUTANEOUS B-CELL LYMPHOMAS
CutaneousB-cell lymphomas (CBCLs) occur less frequently than cutaneous
T-cell lymphomas and account for 20%–25% of all cutaneous lymphomas.
There are 4 primary types ofCBCLs; themost common is primary cutaneous
marginal zoneB-cell lymphoma (PCMZL), followed by primary cutaneous
follicle center lymphoma (PCFCL), primary cutaneous diffuse largeB-cell
lymphoma, leg type (PCLBCL-LT), andprimary cutaneous diffuse largeB-cell
lymphoma, non-leg type (
Table3
).BothPCMZL andPCFCL are slow-
growing forms ofCBCL,with an estimated 5-year survival rate ofmore than
95%.
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On the other hand,whilePCLBCL-LT is a rare type ofCBCL, it grows
into large tumors and ismore likely to spread to other parts of the body. It has
an estimated 5-year survival rate of approximately 59%.
Table3.
Types ofCBCLs
Classification
Although a staging system forCBCLs has not beendeveloped yet, theWorld
HealthOrganization and theEuropeanOrganization forResearch and
Treatment ofCancer developed a system for classifying the 3majorCBCL
entities (PCMZL,PCFCL, andPCLBCL-LT) in aTNM system that
considers the amount of skin involvement of the tumor (T), involvement of the
lymphnodes (N), andwhether the tumor hasmetastasized (M) to involve other
lymphnodes (
Table4
).
1,56
Comprehensive lymphoma stagingwith laboratory
imaging and bonemarrow biopsy are important for determining the prognosis.
Cutaneous B-Cell
Lymphomas
Primary cutaneous follicle center lymphoma (PCFCL)
Primary cutaneousmarginal zoneB-cell lymphoma (PCMZL)
Primary cutaneous diffuse largeB-cell lymphoma, leg type
(PCLBCL-LT)
Primary cutaneous diffuse largeB-cell lymphoma, non-leg type
